Ibigo bikomeye bikora imiti, Moderna na Merck, byatangaje ibisubizo bishimishije by’igeragezwa rya nyuma ry’urukingo rwa mRNA rwihariye ku murwayi wa kanseri, rwatanzwe mu kuvura melanoma, ubwoko bwa kanseri y’uruhu bushobora gukomera cyane.
Ku wa 19 Kanama 2026, Moderna na Merck byatangaje ko urukingo rwitwa intismeran autogene, ruzwi kandi nka V940 cyangwa mRNA-4157, rwageze ku ntego z’ingenzi mu igeragezwa rya kliniki rya Phase 3.
Uru rukingo rwakorewe abarwayi bari bafite melanoma iri mu byiciro bya IIB kugeza kuri IV, bari bamaze kubagwa bakavanwamo kanseri, ariko bagifite ibyago byo kongera kurwara cyangwa kanseri igakwirakwira mu bindi bice by’umubiri.
Urukingo rutandukanye n’izisanzwe
Intismeran autogene ntabwo ari urukingo rusanzwe rutangwa ku bantu bose kugira ngo rubarinde indwara mbere y’uko bayandura.
Ni uburyo bushya bwitwa personalized cancer vaccine, aho urukingo rutegurwa hashingiwe ku miterere yihariye ya kanseri y’umurwayi.
Ikoranabuhanga rya mRNA rikoreshwa mu guha umubiri amabwiriza afasha ubudahangarwa kumenya ibimenyetso byihariye bya kanseri, kugira ngo bushobore gutera uturemangingo twa kanseri dushobora kuba twarasigaye mu mubiri nyuma yo kubagwa.
Rwatanzwe hamwe na Keytruda
Mu igeragezwa, uru rukingo rwahujwe na Keytruda (pembrolizumab), umuti usanzwe ukoreshwa mu gufasha ubudahangarwa bw’umubiri kurwanya kanseri.
Ibisubizo byagaragaje ko uru ruhurirane rwagize umusaruro uruta gukoresha Keytruda yonyine, haba mu kongera igihe abarwayi bamara batongeye kugira ibimenyetso bya kanseri ndetse no mu kugabanya ibyago byo kuba kanseri yakwirakwira mu bindi bice by’umubiri.
Ibi bifatwa nk’intambwe ikomeye mu bushakashatsi bw’urukingo rwa kanseri rwihariye ku murwayi, kuko ari ubwa mbere ubu buryo bugera kuri Phase 3 bukagaragaza ibisubizo bishimishije.
Bashaka kurugerageza no ku zindi kanseri
Moderna na Merck ntibashaka kugarukira kuri melanoma gusa.
Ibigo byombi birimo gukora ubushakashatsi ku ikoreshwa ry’uru rukingo mu zindi kanseri zirimo kanseri y’ibihaha, uruhago n’impyiko, ndetse n’izindi ndwara za kanseri.
Niba ubushakashatsi bukomeje gutanga ibisubizo byiza, ubu buryo bushobora guhindura uko kanseri ivurwa, aho abaganga bashobora kujya bategura uburyo bwo kuvura hashingiwe ku miterere yihariye ya kanseri ya buri murwayi.
Si urukingo rukiza kanseri zose
Nubwo ibisubizo byatangajwe bitanga icyizere, uru rukingo ntiruvuze ko habonetse umuti ukiza kanseri zose.
Haracyakenewe ubushakashatsi burambuye ku mikorere yarwo, umutekano ndetse n’igihe abarwayi bashobora kumara batongeye kurwara.
Moderna na Merck biteganya gutangaza ibisobanuro birambuye by’igeragezwa mu nama z’abahanga, ndetse no kuganira n’inzego zishinzwe kwemeza imiti ku ntambwe ikurikira.
Intambwe nshya mu buvuzi bwa kanseri
Ubushakashatsi kuri uru rukingo bugaragaza icyerekezo gishya mu buvuzi bwa kanseri, aho ikoranabuhanga rya mRNA rishobora gukoreshwa mu gutegura ubuvuzi bwihariye kuri buri murwayi.
Niba uru rukingo ruzakomeza kugaragaza umusaruro mwiza kandi rukemerwa n’inzego zibishinzwe, rushobora gufasha kwimakaza uburyo bwo kuvura kanseri butareba abarwayi bose kimwe, ahubwo bushingiye ku miterere y’umurwayi na kanseri afite.
Icy’ingenzi ni uko iyi ntambwe itavuga ko habonetse “urukingo rumwe rukiza kanseri zose”, ahubwo igaragaza ko mRNA ishobora kuba imwe mu ikoranabuhanga rizafasha ubuvuzi bwa kanseri kujya burushaho kuba ubwihariye kuri buri murwayi.
Rwandatribune.rw
